Sodium bis(trimethylsilyl)amide → tert-butyl 4-(6-bromo-2-oxoquinolin-1(2H)-yl)butylcarbamate

Beteiligte Stoffe

Reaktionsschritte

To a solution of 6-bromoquinolin-2(1H)-one (430 mg, 1.91 mmol) in tetrahydrofuran (8 ml) was added sodium bis(trimethylsilyl)amide (2.1 ml, 2.08 mmol). After 15 minutes, 4-(boc-amino)butyl bromide (403 mg, 1.6 mmol) was added. The solution was stirred for 15 hours, concentrated and purified by flash chromatography to provide the title compound.

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