Sodium Hydroxide → 5-Iodo-2-methoxy-4-methylbenzoic acid

HRID 624308Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 624308
[I:1][C:2]1[C:3]([CH3:14])=[CH:4][C:5]([O:12][CH3:13])=[C:6]([CH:11]=1)[C:7]([O:9]C)=[O:8].[OH-].[Na+]>C(O)C>[I:1][C:2]1[C:3]([CH3:14])=[CH:4][C:5]([O:12][CH3:13])=[C:6]([CH:11]=1)[C:7]([OH:9])=[O:8]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 29934724Methyl 5-iodo-2-methoxy-4-methylbenzoate

Produkt 1

HCID 468293605-Iodo-2-methoxy-4-methylbenzoic acidAusbeute 76,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a mixture of methyl 5-iodo-2-methoxy-4-methylbenzoate (3.0 g, 9.80 mmol) in ethanol (10 ml) in a 50 ml RB flask was added an aqueous solution of NaOH (0.784 g, 19.60 mmol, 1M). The reaction mixture was stirred at room temperature overnight. The solvent was removed under vacuum, the solid filtered and dried to give the titled compound (2.2 g, 74%). LCMS: (ES+) m/z=292 (M+H)+; Column. PUROSPHER@star RP-18 (4×55) mm, 3 μm; Buffer: 20 mM NH4OAc IN WATER; Mphase A: Buffer+MeCN (90+10); Mphase B: Buffer+MeCN (10+90); Flow: 2.5 ml/min Time (min.): 0 2 2.5 3; % B: 0 100 100 0; RT: 1.04 min.

Aufarbeitung

  1. customThe solvent was removed under vacuum
  2. filtrationthe solid filtered
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-e27a0f9893b4462caed620253f2a30ad
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09303020B2

Notizen zur Reaktion

Wird geladen…