Methanol → 6-Methoxy-1H-indol-5-ol

HRID 624380Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 624380
C([O:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][C:17]=1[O:18][CH3:19])[NH:14][CH:13]=[CH:12]2)C1C=CC=CC=1.CO.[H][H]>[OH-].[OH-].[Pd+2].C(OCC)(=O)C>[CH3:19][O:18][C:17]1[CH:16]=[C:15]2[C:11]([CH:12]=[CH:13][NH:14]2)=[CH:10][C:9]=1[OH:8]

Komponenten

6

Edukt 3

HCID 887MethanolHCID 2608005-Benzyloxy-6-methoxyindoleHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 1649576-Methoxy-1H-indol-5-ol

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 9942167Palladium hydroxideKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

5-(benzyloxy)-6-methoxy-1H-indole (3.00 g) was added to methanol (100 mL) and ethyl acetate (100 mL) in a pressure bottle. Palladium hydroxide on carbon (0.832 g) was added and the solution was shaken under 30 psi of hydrogen at room temperature for 40 minutes. The mixture was filtered through a nylon membrane, the solvent removed under vacuum, the residue taken up in ethyl acetate, the solution was filtered over a pad of silica gel, and the solvent was removed from the filtrate under vacuum.

Aufarbeitung

  1. filtrationThe mixture was filtered through a nylon membrane
  2. customthe solvent removed under vacuum
  3. filtrationthe solution was filtered over a pad of silica gel
  4. customthe solvent was removed from the filtrate under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-bf64eb067f644eb1ac2abfe43f46c627
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09303025B2

Notizen zur Reaktion

Wird geladen…