Triethylamine → HCID 178521573, Verbindung

HRID 624412Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 624412
[NH2:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([OH:8])[CH2:4][CH2:3]1.Br[CH2:10][CH2:11][O:12][CH2:13][CH2:14]Br.C(N(CC)CC)C>C(#N)C>[O:12]1[CH2:13][CH2:14][N:1]([C@H:2]2[CH2:7][CH2:6][C@H:5]([OH:8])[CH2:4][CH2:3]2)[CH2:10][CH2:11]1

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 21521Bis(2-bromoethyl) etherHCID 178511715HCID 178511715, Verbindung

Produkt 1

HCID 178521573HCID 178521573, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

Trans-4-aminocyclohexanol (0.5 g), 1-bromo-2-(2-bromoethoxy)ethane (1.07 g) and triethylamine (2.42 mL) were dissolved in anhydrous acetonitrile (20 mL). The reaction mixture was heated at 60° C. overnight. The organic solvent was removed under vacuum. The residue was purified by flash column chromatography on silica gel eluting with 7-10% methanol in dichloromethane to give the title compound.

Aufarbeitung

  1. customThe organic solvent was removed under vacuum
  2. customThe residue was purified by flash column chromatography on silica gel eluting with 7-10% methanol in dichloromethane

Quellen und Nachweise

ORD-Eintrag
ord-a6ae6ec7832c4eb8b39184f70146f919
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09303025B2

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