Dichloromethane → (4-fluorotetrahydro-2H-pyran-4-yl)methanamine

HRID 624419Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 624419
[F:1][C:2]1([CH2:8][N:9]2C(=O)C3C(=CC=CC=3)C2=O)[CH2:7][CH2:6][O:5][CH2:4][CH2:3]1.NN.C(Cl)Cl>C(O)C>[F:1][C:2]1([CH2:8][NH2:9])[CH2:7][CH2:6][O:5][CH2:4][CH2:3]1

Komponenten

5

Edukt 3

HCID 6344DichloromethaneHCID 9321HydrazineHCID 671270062-((4-Fluorotetrahydro-2h-pyran-4-yl)methyl)isoindoline-1,3-dione

Produkt 1

HCID 46856407(4-fluorotetrahydro-2H-pyran-4-yl)methanamine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of EXAMPLE 337B (1.4 g) and hydrazine (1.548 mL) in ethanol (40 mL) was heated at 70° C. overnight, cooled to room temperature, slurried with CH2Cl2 (200 mL) and the solid removed by filtration. The filtrate was concentrated and chromatographed on silica gel with 100:5:1 ethyl acetate/methanol/NH4OH as eluent to give the product.

Aufarbeitung

  1. customthe solid removed by filtration
  2. concentrationThe filtrate was concentrated
  3. customchromatographed on silica gel with 100:5:1 ethyl acetate/methanol/NH4OH as eluent
  4. customto give the product

Quellen und Nachweise

ORD-Eintrag
ord-eb1c9102a9ff48e6ae2c114e01327f25
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09303025B2

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