(2-Amino-4-chlorophenyl)methanol → 2-Amino-4-chlorobenzaldehyde
Reaktionsgleichung
[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH2:9][OH:10]>C(Cl)Cl.[O-2].[Mn+4].[O-2]>[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH:9]=[O:10]Komponenten
4
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
In a 2 L 3-neck round bottom flask, the stirred solution of (2-amino-4-chlorophenyl)methanol 2 (32 g, 203.82 mmol) in DCM (765 mL), manganese (IV) oxide (150 g, 1.724 mol) was added at rt. The resulting reaction mixture was stirred at rt under argon atmosphere for 40 h. On completion of reaction the reaction mixture was filtered through CELITE™ pad and solid residue was washed thoroughly with DCM (1000 mL). The combined filtrate was concentrated under reduced pressure to give 2-amino-4-chlorobenzaldehyde as orange solid.
Aufarbeitung
- customThe resulting reaction mixture
- customOn completion of reaction the reaction mixture
- filtrationwas filtered through CELITE™ pad and solid residue
- washwas washed thoroughly with DCM (1000 mL)
- concentrationThe combined filtrate was concentrated under reduced pressure
Quellen und Nachweise
- ORD-Eintrag
- ord-5996c7a069f843cfb8f7ee178a944e43
- Quelldatensatz
- uspto-grants-2016_04
- Patentnummer
- US09303028B2
Notizen zur Reaktion
Wird geladen…