(2-Amino-4-chlorophenyl)methanol → 2-Amino-4-chlorobenzaldehyde

HRID 624526

Reaktionsgleichung

Reaktionsgleichung von HRID 624526
[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH2:9][OH:10]>C(Cl)Cl.[O-2].[Mn+4].[O-2]>[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH:9]=[O:10]

Komponenten

4

Edukt 1

HCID 4134900(2-Amino-4-chlorophenyl)methanol

Produkt 1

HCID 112521382-Amino-4-chlorobenzaldehyde

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418406HCID 178418406, VerbindungKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

In a 2 L 3-neck round bottom flask, the stirred solution of (2-amino-4-chlorophenyl)methanol 2 (32 g, 203.82 mmol) in DCM (765 mL), manganese (IV) oxide (150 g, 1.724 mol) was added at rt. The resulting reaction mixture was stirred at rt under argon atmosphere for 40 h. On completion of reaction the reaction mixture was filtered through CELITE™ pad and solid residue was washed thoroughly with DCM (1000 mL). The combined filtrate was concentrated under reduced pressure to give 2-amino-4-chlorobenzaldehyde as orange solid.

Aufarbeitung

  1. customThe resulting reaction mixture
  2. customOn completion of reaction the reaction mixture
  3. filtrationwas filtered through CELITE™ pad and solid residue
  4. washwas washed thoroughly with DCM (1000 mL)
  5. concentrationThe combined filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-5996c7a069f843cfb8f7ee178a944e43
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09303028B2

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