Urea → HCID 178517487, Verbindung

HRID 624527

Reaktionsgleichung

Reaktionsgleichung von HRID 624527
[NH2:1][C:2]1[CH:9]=[C:8]([Cl:10])[CH:7]=[CH:6][C:3]=1[CH:4]=O.[NH2:11][C:12](N)=[O:13]>>[Cl:10][C:8]1[CH:9]=[C:2]2[C:3]([CH:4]=[N:11][C:12]([OH:13])=[N:1]2)=[CH:6][CH:7]=1

Komponenten

3

Edukt 2

HCID 1176UreaHCID 112521382-Amino-4-chlorobenzaldehyde

Produkt 1

HCID 178517487HCID 178517487, Verbindung

Reaktionsbedingungen

Temperatur
170 °C

Versuchsvorschrift

In a 500 mL round bottom flask, the uniform mixture of 2-amino-4-chlorobenzaldehyde (16 g, 103.2 2 mmol) and urea (123.8 g, 2063 mmol) was heated at 170° C. with vigorous stirring for 2 h. On completion of reaction, the reaction mixture was cooled to rt and diluted with ice-cold water. The solid that formed was collected by filtration and washed with ice-cold water. The solid was dried under reduced pressure to give crude 7-chloroquinazolin-2-ol as a yellow solid. Yield: 19 g. LCMS (ESI, m/z): 181 (M+1)+

Aufarbeitung

  1. customOn completion of reaction
  2. temperaturethe reaction mixture was cooled to rt
  3. additiondiluted with ice-cold water
  4. customThe solid that formed
  5. filtrationwas collected by filtration
  6. washwashed with ice-cold water
  7. customThe solid was dried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-b28a4f0b61c14aa5a3ef1d4a8e03b04b
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09303028B2

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