Hydrochloric Acid → Olanzamine

HRID 624541

Reaktionsgleichung

Reaktionsgleichung von HRID 624541
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9]1[S:10][C:11]([CH3:16])=[CH:12][C:13]=1[C:14]#[N:15].Cl>C(O)(C)C>[CH3:16][C:11]1[S:10][C:9]2[NH:8][C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=3[N:1]=[C:14]([NH2:15])[C:13]=2[CH:12]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 674452622-(2-Aminoanilino)-5-methylthiophene-3-carbonitrile

Produkt 1

HCID 135446208Olanzamine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

A mixture of 2-((2-aminophenyl)amino)-5-methylthiophene-3-carbonitrile, prepared as described in the previous step, (22.9 g, 100 mmol) in isopropanol (150 mL) and aqueous hydrochloric acid (50 mL, 18%) was heated at 80° C. for 3 hrs. The resulting suspension was filtered and the filter cake was dried to give the title compound as a red solid. 1H NMR (400 MHz CDCl3) δ 7.14-7.12 (t, 1H), 7.7.12-7.10 (t, 1H), 6.95-6.93 (d, J=8 MHz, 1H), 6.81-6.79 (d, J=8 MHz, 1H), 6.70 (s, 1H), 2.30 (s, 3H).

Aufarbeitung

  1. customprepared
  2. filtrationThe resulting suspension was filtered
  3. customthe filter cake was dried

Quellen und Nachweise

ORD-Eintrag
ord-2ca7f3dccaf54b94af280e276549d8e9
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09303041B2

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