4-Fluorobenzoyl chloride → 6-(2-Amino-ethyl)-5-(4-fluoro-phenyl)-1,3-dimethyl-1,6-dihydro-pyrrolo[3,4-d]pyrimidine-2,4-dione
Reaktionsgleichung
[NH2:1][CH2:2][CH2:3][N:4]1[C:12]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[C:11]2[C:6]([N:7]([CH3:22])[C:8](=[O:21])[N:9]([CH3:20])[C:10]2=[O:19])=[CH:5]1.[F:23]C1C=CC(C(Cl)=O)=CC=1>>[NH2:1][CH2:2][CH2:3][N:4]1[C:12]([C:13]2[CH:18]=[CH:17][C:16]([F:23])=[CH:15][CH:14]=2)=[C:11]2[C:6]([N:7]([CH3:22])[C:8](=[O:21])[N:9]([CH3:20])[C:10]2=[O:19])=[CH:5]1Komponenten
3
Versuchsvorschrift
This compound was prepared analogously to Intermediate A by replacing benzoyl chloride (step 2) with 4-fluorobenzoyl chloride.
Quellen und Nachweise
- ORD-Eintrag
- ord-7197b6a1a33844d499dd3b81e6754682
- Quelldatensatz
- uspto-grants-2016_04