Methylamine → 2-Amino-5-fluoro-N-methylbenzamide
Reaktionsgleichung
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:10]C(=O)[O:8][C:7](=O)[C:6]=2[CH:13]=1.[CH3:14][NH2:15]>O1CCCC1>[NH2:10][C:5]1[CH:4]=[CH:3][C:2]([F:1])=[CH:13][C:6]=1[C:7]([NH:15][CH3:14])=[O:8]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
6-Fluoro-2H-3,1-benzoxazine-2,4(1H)-dione (200 mg, 1.104 mmol) was dissolved in dry tetrahydrofuran (THF) (10 mL), at which time methyl amine (3.31 mL, 6.63 mmol) was added. The reaction was stirred at room temperature for 1 h, then concentrated under vacuum. The crude product was purified on silica (Biotage, 40% EtOAc/hexene) to afford the title compound (120 mg, 65%) as a white solid. LC-MS (ES) m/z=169.1 (M+H)+
Aufarbeitung
- additionwas added
- concentrationconcentrated under vacuum
- customThe crude product was purified on silica (Biotage, 40% EtOAc/hexene)
Quellen und Nachweise
- ORD-Eintrag
- ord-aef9e4fc5a7a44e5a961eff5a775f7f9
- Quelldatensatz
- uspto-grants-2016_09
- Patentnummer
- US09446034B2
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