N-(1,1-Dimethylethyl)benzenemethanamine → 6-Cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid benzyl-tert-butyl-amide

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	N-(1,1-Dimethylethyl)benzenemethanamine	HCID 76908	—
Edukt	Diisopropylethylamine	HCID 81531	—
Edukt	O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate	HCID 2733207	—
Edukt	6-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinic acid	HCID 71087292	—
Produkt	6-Cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid benzyl-tert-butyl-amide	HCID 76283583	—

Reaktionsschritte

In analogy to the procedure described in Example 47 b), 6-cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (Example 1 b)) was reacted with N-benzyl-2-methylpropan-2-amine (CAN 3378-72-1) in the presence of TBTU and DIEA to obtain the title compound as colorless solid; MS (EI): m/e=430.5 [MH+].

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US09303012B2
Quelldatensatz	uspto-grants-2016_04
ORD ID	ord-7e033d80a5864b97ae1a6f4a102485a8
Quellennotiz	uspto-grants-2016_04