Methyl iodide → (+)-6-Cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid methyl-(3-methyl-1-pyridazin-3-yl-butyl)-amide

HRID 624896Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 624896
[CH3:1][CH:2]([CH3:31])[CH2:3][CH:4]([NH:11][C:12]([C:14]1[CH:19]=[CH:18][C:17]([N:20]2[CH2:23][C:22]([F:25])([F:24])[CH2:21]2)=[C:16]([O:26][CH2:27][CH:28]2[CH2:30][CH2:29]2)[N:15]=1)=[O:13])[C:5]1[N:6]=[N:7][CH:8]=[CH:9][CH:10]=1.[CH3:32]I.[H-].[Na+]>>[CH3:32][N:11]([CH:4]([C:5]1[N:6]=[N:7][CH:8]=[CH:9][CH:10]=1)[CH2:3][CH:2]([CH3:31])[CH3:1])[C:12]([C:14]1[CH:19]=[CH:18][C:17]([N:20]2[CH2:21][C:22]([F:25])([F:24])[CH2:23]2)=[C:16]([O:26][CH2:27][CH:28]2[CH2:30][CH2:29]2)[N:15]=1)=[O:13]

Komponenten

4

Edukt 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 711057036-Cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (3-methyl-1-pyridazin-3-yl-butyl)-amide

Produkt 1

HCID 90203545(+)-6-Cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid methyl-(3-methyl-1-pyridazin-3-yl-butyl)-amide

Versuchsvorschrift

In analogy to the procure described in Example 16 b), (+)-6-cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (3-methyl-1-pyridazin-3-yl-butyl)-amide was reacted with methyl iodide (CAN 74-88-4) in the presence of sodium hydride to give the title compound as colorless oil; MS (EI): m/e=446.2 [MH]+.

Quellen und Nachweise

ORD-Eintrag
ord-137ea82a271b4e6693405bd5caa7e0d6
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09303012B2

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