4,4-Difluoro-L-prolinamide hydrochloride → (S)-1-(5-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carbonyl)-4,4-difluoro-pyrrolidine-2-carboxylic acid amide

HRID 624930Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 624930
[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:15]([OH:17])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:14][CH2:13]2)[CH2:3][CH2:2]1.Cl.[F:19][C:20]1([F:28])[CH2:24][NH:23][C@H:22]([C:25]([NH2:27])=[O:26])[CH2:21]1>>[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:15]([N:23]3[CH2:24][C:20]([F:28])([F:19])[CH2:21][C@H:22]3[C:25]([NH2:27])=[O:26])=[O:17])=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:13][CH2:14]2)[CH2:2][CH2:3]1

Komponenten

3

Edukt 2

HCID 451589094,4-Difluoro-L-prolinamide hydrochlorideHCID 710873465-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid

Produkt 1

HCID 90203444(S)-1-(5-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carbonyl)-4,4-difluoro-pyrrolidine-2-carboxylic acid amide

Versuchsvorschrift

The title compound was synthesized in analogy to Example 47 b, using 5-cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid (Example 3 c, 50 mg, 214 μmol) and (2S)-4,4-difluoro-2-pyrrolidinecarboxamide hydrochloride (CAN 426844-51-1; 44 mg, 236 μmol) as starting materials and isolated (63 mg, 80%) as off-white solid; LC-MS (UV peak area, ESI) 100%, 366.1629 [MH+].

Aufarbeitung

  1. customisolated (63 mg, 80%) as off-white solid

Quellen und Nachweise

ORD-Eintrag
ord-5370fd473c0c4aae87d5618f1306a32c
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09303012B2

Notizen zur Reaktion

Wird geladen…