HCID 86711148, Verbindung → tert-Butyl 3-(aminomethyl)-4-(2-(2-hydroxyethoxy)ethyl)piperazine-1-carboxylate

HRID 625171Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 625171
[C:1]([CH:3]1[N:8]([CH2:9][CH2:10][O:11][CH2:12][CH2:13][OH:14])[CH2:7][CH2:6][N:5]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:4]1)#[N:2]>CO.[Ni]>[NH2:2][CH2:1][CH:3]1[N:8]([CH2:9][CH2:10][O:11][CH2:12][CH2:13][OH:14])[CH2:7][CH2:6][N:5]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:4]1

Komponenten

4

Edukt 1

HCID 86711148HCID 86711148, Verbindung

Produkt 1

HCID 86711149tert-Butyl 3-(aminomethyl)-4-(2-(2-hydroxyethoxy)ethyl)piperazine-1-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of tert-butyl 3-cyano-4-(2-(2-hydroxyethoxy)ethyl)piperazine-1-carboxylate, prepared as described in the previous step, (9.9 g, 33.1 mmol) in methanol (20 mL) was added Raney Ni (15 g). The reaction solution was stirred at room temperature overnight under hydrogen atmosphere (50 psi). The mixture was filtered and concentrated to provide the product, which was used in the next step without additional purification.

Aufarbeitung

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated
  3. customto provide the product, which
  4. customwas used in the next step without additional purification

Quellen und Nachweise

ORD-Eintrag
ord-2dd9145331b94ac994de69388b47a037
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09304126B2

Notizen zur Reaktion

Wird geladen…