Ethanethiol, 2-(methylamino)-, hydrochloride → HCID 72680490, Verbindung
Reaktionsgleichung
[Cl:1][C:2]1[O:3][C:4]2[CH:10]=[CH:9][C:8]([C:11]([CH2:27][CH3:28])=[C:12]([C:20]3[CH:25]=[CH:24][C:23]([OH:26])=[CH:22][CH:21]=3)[C:13]3[CH:14]=[N:15][C:16](Cl)=[CH:17][CH:18]=3)=[CH:7][C:5]=2[CH:6]=1.Cl.[CH3:30][NH:31][CH2:32][CH2:33][SH:34]>>[Cl:1][C:2]1[O:3][C:4]2[CH:10]=[CH:9][C:8]([C:11]([CH2:27][CH3:28])=[C:12]([C:20]3[CH:21]=[CH:22][C:23]([OH:26])=[CH:24][CH:25]=3)[C:13]3[CH:14]=[N:15][C:16]([S:34][CH2:33][CH2:32][NH:31][CH3:30])=[CH:17][CH:18]=3)=[CH:7][C:5]=2[CH:6]=1Komponenten
3
Versuchsvorschrift
According to the same procedure as example 16, step C described, 4-(2-(2-chlorobenzofuran-5-yl)-1-(6-chloropyridin-3-yl)but-1-enyl)phenol (70 mg, 1.0 eq) was reacted with 2-(methylamino)ethanethiol hydrochloride (217 mg, 10 eq) to give the desired product (Z/E=1/1). m/z=465[M+1]+.
Quellen und Nachweise
- ORD-Eintrag
- ord-e58124ed9e134ca88db72a02332a8152
- Quelldatensatz
- uspto-grants-2016_04