Reaktionsgleichung
[CH3:1][NH:2][CH2:3][CH2:4]C.[O:6]1[CH2:9]C(N)C1.C1(C2C=CC([N+]([O-])=[O:24])=C(C=2)N)CCCC=1.[N+:26]([C:29]1[CH:35]=[CH:34][C:33]([C:36]2[S:37][CH:38]=[CH:39][CH:40]=2)=[CH:32][C:30]=1[NH2:31])([O-])=O>>[NH2:26][C:29]1[CH:35]=[CH:34][C:33]([C:36]2[S:37][CH:38]=[CH:39][CH:40]=2)=[CH:32][C:30]=1[NH:31][C:1]([NH:2][CH:3]1[CH2:4][O:6][CH2:9]1)=[O:24]Komponenten
5
Versuchsvorschrift
1-(2-amino-5-(thiophen-2-yl)phenyl)-3-(oxetan-3-yl)urea was prepared by substituting N-methylpropan-1-amine in Scheme 25 with oxetan-3-amine and by substituting 5-(cyclopent-1-en-1-yl)-2-nitroaniline in Scheme 25 with 2-nitro-5-(thiophen-2-yl)aniline. ESI+ MS: m/z 289 ([M]+), 1H NMR (500 MHz, d6-DMSO): δ 7.67 (s, 1H), 7.59 (s, 1H), 7.33 (d, J=4.5 Hz, 1H), 7.18 (d, J=2.5 Hz, 1H), 7.12 (d, J=8.0 Hz, 1H), 7.05-6.96 (m, 2H), 6.73 (d, J=8.0 Hz, 1H), 4.93 (bs, 2H), 4.82-4.70 (m, 3H), 4.47-4.43 (m, 2H).
Quellen und Nachweise
- ORD-Eintrag
- ord-86382b4e18fe476b9eec60e56798988d
- Quelldatensatz
- uspto-grants-2016_09
- Patentnummer
- US09447030B2
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