Hydrochloric Acid → Methyl 4-hydroxypiperidine-4-carboxylate

HRID 626964Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 626964
Cl.[OH:2][C:3]1([C:9]([OH:11])=[O:10])[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1.Cl.[CH3:13]O>>[OH:2][C:3]1([C:9]([O:11][CH3:13])=[O:10])[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 533992144-Hydroxypiperidine-4-carboxylic acid--hydrogen chloride (1/1)

Produkt 1

HCID 21093366Methyl 4-hydroxypiperidine-4-carboxylate

Versuchsvorschrift

4-Hydroxy-4-piperidinecarboxylic acid hydrochloride salt (1 g, 5.1 mmol) was added to a 2% hydrochloric acid solution in methanol (25 mL) and the mixture was stirred at room temperature overnight. The solvent was removed under reduced pressure to give the title compound as the hydrochloride salt (1 g, 92%) as a white solid. δH (400 MHz, DMSO-d6) 9.06 (broad, 2H), 5.89 (broad, 1H), 3.68 (m, 3H), 3.14 (m, 2H), 3.02 (m, 2H), 2.07 (m, 2H), 1.79 (m, 2H).

Aufarbeitung

  1. customThe solvent was removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-9bec0bbae83847e2abd67b15afc1fc2d
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09309243B2

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