HCID 89852058, Verbindung → (3R,6S)-3-(allyloxyamino)-6-(methoxymethyl)-1,2,3,6-tetrahydro-pyridine-4-carboxamide

HRID 627147Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 627147
[CH2:1]([O:4][N:5]([C@@H:18]1[C:23]([C:24]([NH2:26])=[O:25])=[CH:22][C@@H:21]([CH2:27][O:28][CH3:29])[NH:20][CH2:19]1)S(C1C=CC=CC=1[N+]([O-])=O)(=O)=O)[CH:2]=[CH2:3].C(ON[C@@H]1C(C(N)=O)=C[C@@H](CO[Si](C(C)(C)C)(C)C)NC1)C=C.C(ON([C@@H]1C(C(N)=O)=C[C@@H](CO[Si](C(C)(C)C)(C)C)NC1)S(C1C=CC([N+]([O-])=O)=CC=1[N+]([O-])=O)(=O)=O)C=C>>[CH2:1]([O:4][NH:5][C@@H:18]1[C:23]([C:24]([NH2:26])=[O:25])=[CH:22][C@@H:21]([CH2:27][O:28][CH3:29])[NH:20][CH2:19]1)[CH:2]=[CH2:3]

Komponenten

4

Edukt 3

HCID 89852058HCID 89852058, Verbindung2×HCID 89852509(3R,6S)-3-(N-(allyloxy)-2,4-dinitrophenylsulfonamido)-6-((tert-butyldimethylsilyloxy)methyl)-1,2,3,6-tetrahydropyridine-4-carboxamideHCID 89852545(3R,6S)-3-(allyloxyamino)-6-((tert-butyldimethylsilyloxy)methyl)-1,2,3,6-tetrahydropyridine-4-carboxamide

Produkt 1

HCID 89852143(3R,6S)-3-(allyloxyamino)-6-(methoxymethyl)-1,2,3,6-tetrahydro-pyridine-4-carboxamide

Versuchsvorschrift

This intermediate was prepared from (3R,6S)-3-(N-(allyloxy)-2-nitrophenylsulfonamido)-6-(methoxymethyl)-1,2,3,6-tetrahydropyridine-4-carboxamide (Intermediate 113, 734 mg, 1.36 mmol) using the same procedure and isolation techniques to prepare Intermediate 107 from Intermediate 106. The title compound was an orange oil (173 mg, 53%).

Quellen und Nachweise

ORD-Eintrag
ord-6c1b09798cf74edfa03c45a290077c0a
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09309245B2

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