Thionyl Chloride → 2-Fluoropyridine-5-carbonyl chloride
Reaktionsgleichung
[F:1][C:2]1[N:7]=[CH:6][C:5]([C:8]([OH:10])=O)=[CH:4][CH:3]=1.S(Cl)([Cl:13])=O>>[F:1][C:2]1[N:7]=[CH:6][C:5]([C:8]([Cl:13])=[O:10])=[CH:4][CH:3]=1Komponenten
3
Reaktionsbedingungen
- Temperatur
- 80 °C
Versuchsvorschrift
In a 100-mL round-bottom flask was placed a solution of 6-fluoropyridine-3-carboxylic acid (5.0 g, 35.4 mmol) in thionyl chloride (20 mL). The resulting solution was heated at 80° C. for 2 hours and concentrated under vacuum to give the title compound as a yellow oil.
Aufarbeitung
- customIn a 100-mL round-bottom flask was placed
- concentrationconcentrated under vacuum
Quellen und Nachweise
- ORD-Eintrag
- ord-7ebacbd88c974eeaa7baa374f072bab9
- Quelldatensatz
- uspto-grants-2016_04
- Patentnummer
- US09309222B2
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