Hydrochloric Acid → 4-Chloro-3,5-diisopropoxybenzoic acid

HRID 62751Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 62751
[Cl:1][C:2]1[C:11]([O:12][CH:13]([CH3:15])[CH3:14])=[CH:10][C:5]([C:6]([O:8]C)=[O:7])=[CH:4][C:3]=1[O:16][CH:17]([CH3:19])[CH3:18].[OH-].[Na+].Cl>>[Cl:1][C:2]1[C:11]([O:12][CH:13]([CH3:14])[CH3:15])=[CH:10][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[O:16][CH:17]([CH3:19])[CH3:18]

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 67041833Methyl 4-chloro-3,5-diisopropoxybenzoate

Produkt 1

HCID 670418114-Chloro-3,5-diisopropoxybenzoic acidAusbeute 68,8 %

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

Methyl 4-chloro-3,5-diisopropoxybenzoate (5) (93 mg, 0.32 mmol) was suspended in 2M sodium hydroxide (1.6 mL, 3.2 mmol) and stirred at 100° C. for 3 h. After cooling to RT the mixture was acidified by the addition of 1 M HCl. The resulting precipitate was collected by filtration and dried in vacuo to afford 4-chloro-3,5-diisopropoxybenzoic acid (6) (60 mg, 66% yield) as a white solid. This material was used in the subsequent reaction step without purification.

Aufarbeitung

  1. temperatureAfter cooling to RT the mixture
  2. filtrationThe resulting precipitate was collected by filtration
  3. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-9c3a79757fb14569bc674a86fcea72ca
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09447028B2

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