C(OC([NH:8][CH:9]([CH2:22][C:23]#[CH:24])[C:10]([NH:12][CH:13]([CH2:18][CH:19]([CH3:21])[CH3:20])[C:14]([O:16][CH3:17])=[O:15])=[O:11])=O)(C)(C)C.[ClH:25].O1CCOCC1>C(Cl)Cl>[Cl-:25].[CH3:17][O:16][C:14](=[O:15])[CH:13]([NH:12][C:10](=[O:11])[CH:9]([NH3+:8])[CH2:22][C:23]#[CH:24])[CH2:18][CH:19]([CH3:21])[CH3:20]A solution of compound 1 (10.55 g: 31 mmol) in DCM (100 mL) was treated with 4M HCl in dioxane (78 mL; 0.31 mol) and stirred at room temperature for 3 h while monitoring the disappearance of the starting material by TLC. The solvent was removed on the rotary evaporator and the residue was treated with ether and then concentrated to give 2 as an off white solid (8.3 g; 96% yield).
Wird geladen…