Methyl 5-(2,2-difluoroethoxy)-3-methylpyrazine-2-carboxylate → 5-(2,2-Difluoroethoxy)-3-methylpyrazine-2-carboxylic acid

HRID 627705Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 627705
[F:1][CH:2]([F:16])[CH2:3][O:4][C:5]1[N:6]=[C:7]([CH3:15])[C:8]([C:11]([O:13]C)=[O:12])=[N:9][CH:10]=1>Cl.O1CCOCC1>[F:16][CH:2]([F:1])[CH2:3][O:4][C:5]1[N:6]=[C:7]([CH3:15])[C:8]([C:11]([OH:13])=[O:12])=[N:9][CH:10]=1

Komponenten

4

Edukt 1

HCID 86728150Methyl 5-(2,2-difluoroethoxy)-3-methylpyrazine-2-carboxylate

Produkt 1

HCID 867281515-(2,2-Difluoroethoxy)-3-methylpyrazine-2-carboxylic acidAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 313Hydrochloric AcidLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

A mixture of methyl 5-(2,2-difluoroethoxy)-3-methylpyrazine-2-carboxylate (63.8 mg, 0.275 mmol) in aqueous 2N HCl (1 mL) and Dioxane (2 mL) was stirred at ambient temperature for 20 hrs. The reaction was concentrated and the resulting solid was rinsed with acetonitrile. The filtrate was collected and concentrated in vacuo to give the title compound (60 mg, 0.275 mmol, 100%) as a white solid. MS m/z=219.1 (M+H).

Aufarbeitung

  1. concentrationThe reaction was concentrated
  2. washthe resulting solid was rinsed with acetonitrile
  3. customThe filtrate was collected
  4. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-adc4f4ef645c432a88f34d06c3fca6ee
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09309263B2

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