3-(4-Hydroxyphenyl)propionic acid → Benzenepropanoic acid, 4-hydroxy-, methyl ester

HRID 62838

Reaktionsgleichung

Reaktionsgleichung von HRID 62838
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]([OH:12])=[O:11])=[CH:4][CH:3]=1.Cl.O1CCOC[CH2:15]1>CO>[CH3:15][O:11][C:10](=[O:12])[CH2:9][CH2:8][C:5]1[CH:4]=[CH:3][C:2]([OH:1])=[CH:7][CH:6]=1

Komponenten

4

Edukt 2

HCID 103943-(4-Hydroxyphenyl)propionic acidHCID 204431481,4-Dioxane hydrochloride

Produkt 1

HCID 79706Benzenepropanoic acid, 4-hydroxy-, methyl esterAusbeute 100,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

After 3-(4-hydroxy-phenyl)propionic acid (3 g, 18 mmol) was added with MeOH (6 mL), 4M HCl/dioxane solution (18 mL, 72 mmol) was added thereto, and the mixture was stirred at room temperature for 3 hours. The reactant was concentrated, added with EtOAc, and then washed with NaCl aqueous solution. The organic layer was separated, dried with MgSO4, and filtered to obtain the title compound (3.26 g, 99%).

Aufarbeitung

  1. additionwas added
  2. concentrationThe reactant was concentrated
  3. additionadded with EtOAc
  4. washwashed with NaCl aqueous solution
  5. customThe organic layer was separated
  6. dry with materialdried with MgSO4
  7. filtrationfiltered

Quellen und Nachweise

ORD-Eintrag
ord-ec3f833bd73143d4a3ef43c7709226b4
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09447044B2

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