[CH2:1]([O:3][C:4](=[O:17])[CH:5]([CH3:16])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13]C)=[C:9]([F:15])[CH:8]=1)C.B(Br)(Br)Br.CO>C(Cl)Cl>[CH3:1][O:3][C:4](=[O:17])[CH:5]([CH3:16])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[C:9]([F:15])[CH:8]=1After 3-(3-fluoro-4-methoxy-phenyl)-2-methyl-propionic acid ethyl ester (0.728 g, 3.03 mmol) obtained in Step B was dissolved in anhydrous DCM (10 mL), 1M BBr3 solution (4.5 mL, 4.5 mmol) was added thereto at −78° C., and the mixture was stirred at room temperature for 3 hours. After the termination of the reaction, the reactant was added with MeOH, concentrated under reduced pressure, and purified by column chromatography (eluent, EtOAc/Hex=1/2) to obtain the title compound (0.64 g, 99%).
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