Cyclopentanethiol → 2-Cyclopentylsulfanyl-6-methoxy-nicotinic acid methyl ester
Reaktionsgleichung
[CH3:1][O:2][C:3](=[O:13])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[N:6][C:5]=1Cl.[CH:14]1([SH:19])[CH2:18][CH2:17][CH2:16][CH2:15]1>>[CH3:1][O:2][C:3](=[O:13])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[N:6][C:5]=1[S:19][CH:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1Komponenten
3
Versuchsvorschrift
2-Chloro-6-methoxy-nicotinic acid methyl ester (54 mg, 0.26 mmol) and cyclopen-tanethiol were reacted in the same manner as in Step A of Preparation Example 16 to obtain the title compound (55 mg, 77%).
Quellen und Nachweise
- ORD-Eintrag
- ord-e70926e9fcc74d7ca1763b3f81742b6f
- Quelldatensatz
- uspto-grants-2016_09
- Patentnummer
- US09447044B2
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