Sulfuric Acid → HCID 90118322, Verbindung

HRID 62895Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 62895
Cl[CH2:2][C:3]1[C:12]2[C:7](=[C:8]([F:15])[C:9]([OH:14])=[C:10]([F:13])[CH:11]=2)[O:6][C:5](=[O:16])[CH:4]=1.S(=O)(=O)(O)[OH:18]>[OH-].[Na+]>[F:13][C:10]1[C:9]([OH:14])=[C:8]([F:15])[C:7]2[O:6][CH:2]=[C:3]([CH2:4][C:5]([OH:16])=[O:18])[C:12]=2[CH:11]=1

Komponenten

4

Edukt 2

HCID 1118Sulfuric AcidHCID 18757590HCID 18757590, Verbindung

Produkt 1

HCID 90118322HCID 90118322, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 14798Sodium HydroxideLösungsmittel

Versuchsvorschrift

4-Chloromethyl-6,8-difluoro-7-hydroxy-2-chromenone (0.2 g, 0.81 mmol) obtained in Step A was dissolved in 1N NaOH aqueous solution (8 mL), and the mixture was stirred under reflux for 2 hours. The reactant was acidified by the addition of sulfuric acid, and then extracted with EtOAc. The organic layer was dried with MgSO4, and distilled under reduced pressure to obtain the title compound (0.16 g).

Aufarbeitung

  1. temperatureunder reflux for 2 hours
  2. extractionextracted with EtOAc
  3. dry with materialThe organic layer was dried with MgSO4
  4. distillationdistilled under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-fa832b321433472cad9a2755ba052a0b
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09447044B2

Notizen zur Reaktion

Wird geladen…