Urea → 5-Methoxypyrimidine-2,4,6-triol

HRID 629027

Reaktionsgleichung

Reaktionsgleichung von HRID 629027
O(C)[Na].[CH3:4][O:5][CH:6]([C:11]([O:13]C)=O)[C:7]([O:9]C)=O.[NH2:15][C:16]([NH2:18])=[O:17]>CCO>[OH:13][C:11]1[NH:18][C:16](=[O:17])[NH:15][C:7](=[O:9])[C:6]=1[O:5][CH3:4]

Komponenten

5

Edukt 3

HCID 1176UreaHCID 78718Dimethyl methoxymalonateHCID 178418582HCID 178418582, Verbindung

Produkt 1

HCID 673031125-Methoxypyrimidine-2,4,6-triolAusbeute 99 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

The NaOCH3 (8.5 g, 157 mmole), was added to a stirred solution of dimethyl 2-methoxymalonate (10.2 g, 62.91 mmole), urea (2.5 g, 41.7 mmole), and EtOH (80 ml). The reaction mixture was heated to 100° C. for 4 hrs, then the reaction was evaporated to remove the solvent. Water was added to the mixture and then concentrated HCl was added. The pH of the mixture was adjusted to ca. 3˜4. The mixture was filtered and wash water and acetone. After drying in vacuo, it gave a product (99%).

Aufarbeitung

  1. customthe reaction was evaporated
  2. customto remove the solvent
  3. additionWater was added to the mixture
  4. additionconcentrated HCl was added
  5. filtrationThe mixture was filtered
  6. washwash water and acetone
  7. customAfter drying in vacuo, it

Quellen und Nachweise

ORD-Eintrag
ord-1d949d18dba545aa9d399ca3657db60d
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09315491B2

Verknüpfte Notizen

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