Potassium Butyltrifluoroborate → Methyl-6-butylbenzofuran-2-carboxylate
Reaktionsgleichung
[CH3:1][O:2][C:3]([C:5]1[O:6][C:7]2[CH:13]=[C:12](Br)[CH:11]=[CH:10][C:8]=2[CH:9]=1)=[O:4].[CH2:15]([B-](F)(F)F)[CH2:16][CH2:17][CH3:18].[K+]>>[CH3:1][O:2][C:3]([C:5]1[O:6][C:7]2[CH:13]=[C:12]([CH2:15][CH2:16][CH2:17][CH3:18])[CH:11]=[CH:10][C:8]=2[CH:9]=1)=[O:4]Komponenten
3
Versuchsvorschrift
Methyl-6-butylbenzofuran-2-carboxylate was synthesized as in Example 3.1 using methyl-6-bromobenzofuran-2-carboxylate (195 mg, 0.76 mmol) in place of 5-bromo-2-formylfuran and potassium butyltrifluoroborate (188 mg, 1.15 mmol) in place of hexylboronic acid to give methyl-6-butylbenzofuran-2-carboxylate (118 mg, 67%). Used without further characterization.
Quellen und Nachweise
- ORD-Eintrag
- ord-63a809f89f9d40b985e6c741c53da17a
- Quelldatensatz
- uspto-grants-2016_04