6-Bromobenzo[b]thiophene-2-carbaldehyde → HCID 118230501, Verbindung

HRID 629168Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 629168
Br[C:2]1[CH:12]=[CH:11][C:5]2[CH:6]=[C:7]([CH:9]=[O:10])[S:8][C:4]=2[CH:3]=1.[F:13][C:14]([F:22])([F:21])[CH2:15][CH2:16][B-](F)(F)F.[K+]>>[F:13][C:14]([F:22])([F:21])[CH2:15][CH2:16][C:2]1[CH:12]=[CH:11][C:5]2[CH:6]=[C:7]([CH:9]=[O:10])[S:8][C:4]=2[CH:3]=1

Komponenten

3

Edukt 2

HCID 568323096-Bromobenzo[b]thiophene-2-carbaldehydeHCID 56972906Potassium 3,3,3-trifluoropropane-1-trifluoroborate

Produkt 1

HCID 118230501HCID 118230501, VerbindungAusbeute 80 %

Versuchsvorschrift

The compound was synthesized as in Example 3.1 using 6-bromobenzothiophene-2-carbaldehyde (50 mg, 0.21 mmol) in place of 5-bromo-2-formylfuran and potassium (3,3,3-trifluoro)propyltrifluoroborate (63 mg, 0.31 mmol) in place of hexylboronic acid to give 6-(3,3,3-trifluoropropyl)benzothiophene-2-carbaldehyde (43 mg, 80%). Used without further characterization.

Quellen und Nachweise

ORD-Eintrag
ord-7c3f69e3c5f44175b15bd924c84fd03d
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09315495B2

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