Ethyl 3-(3,5-difluoro-4-hydroxyphenyl)propanoate → HCID 74222282, Verbindung

HRID 62926Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 62926
Cl[CH2:2][C:3]1[C:4]([S:9][CH2:10][CH:11]([CH3:13])[CH3:12])=[N:5][CH:6]=[CH:7][CH:8]=1.C([O:16][C:17](=[O:29])[CH2:18][CH2:19][C:20]1[CH:25]=[C:24]([F:26])[C:23]([OH:27])=[C:22]([F:28])[CH:21]=1)C>>[F:26][C:24]1[CH:25]=[C:20]([CH2:19][CH2:18][C:17]([OH:29])=[O:16])[CH:21]=[C:22]([F:28])[C:23]=1[O:27][CH2:2][C:3]1[C:4]([S:9][CH2:10][CH:11]([CH3:13])[CH3:12])=[N:5][CH:6]=[CH:7][CH:8]=1

Komponenten

3

Edukt 2

HCID 23136305Ethyl 3-(3,5-difluoro-4-hydroxyphenyl)propanoateHCID 90118329HCID 90118329, Verbindung

Produkt 1

HCID 74222282HCID 74222282, VerbindungAusbeute 60 %

Versuchsvorschrift

3-Chloromethyl-2-isobutylsulfanyl-pyridine (0.048 g, 0.22 mmol) obtained in Step C of Preparation Example 12 and 3-(3,5-difluoro-4-hydroxy-phenyl)-propionic acid ethyl ester (0.051 g, 0.22 mmol) obtained in Step D of Preparation Example 2 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (60% yield).

Aufarbeitung

  1. customto react sequentially in the same manner as in Steps A and B of Example 1

Quellen und Nachweise

ORD-Eintrag
ord-1c20d20735884a058afc1bbdf2d9eb28
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09447044B2

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