Methanol → Methyl 4-bromo-2-hydroxybenzoate

HRID 629468

Reaktionsgleichung

Reaktionsgleichung von HRID 629468
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4]([OH:11])[CH:3]=1.S(Cl)(Cl)=O.[CH3:16]O>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([O:8][CH3:16])=[O:7])=[C:4]([OH:11])[CH:3]=1

Komponenten

4

Edukt 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 2687374-Bromo-2-hydroxybenzoic acid

Produkt 1

HCID 13983552Methyl 4-bromo-2-hydroxybenzoate

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

To a solution of 4-bromo-2-hydroxybenzoic acid (15.0 g) in methanol (150 mL) was added dropwise thionyl chloride (10.1 mL) under ice-cooling. The reaction solution was stirred at 70° C. overnight under argon atmosphere. The reaction solution was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (14.2 g).

Aufarbeitung

  1. temperaturecooling
  2. concentrationThe reaction solution was concentrated under reduced pressure
  3. customthe residue was purified by silica gel column chromatography (ethyl acetate/hexane)

Quellen und Nachweise

ORD-Eintrag
ord-61b8939524814cf1815267b66a53429f
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09315458B2

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