2-Hydroxy-4-vinyl-benzoic acid methyl ester → Methyl 4-ethyl-2-hydroxybenzoate

HRID 629470

Reaktionsgleichung

Reaktionsgleichung von HRID 629470
[OH:1][C:2]1[CH:11]=[C:10]([CH:12]=[CH2:13])[CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5]>C(O)C.[C].[Pd]>[CH2:12]([C:10]1[CH:9]=[CH:8][C:3]([C:4]([O:6][CH3:7])=[O:5])=[C:2]([OH:1])[CH:11]=1)[CH3:13]

Komponenten

4

Edukt 1

HCID 200893762-Hydroxy-4-vinyl-benzoic acid methyl ester

Produkt 1

HCID 54092218Methyl 4-ethyl-2-hydroxybenzoateAusbeute 61,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of methyl 2-hydroxy-4-vinylbenzoate (2.31 g) in ethanol (25.0 mL) was added palladium-carbon (1.38 g), and the mixture was stirred overnight at room temperature under hydrogen atmosphere. The insoluble substance was removed by filtration, and the filtrate was concentrated under reduced pressure. The obtained residue was purified by NH silica gel column chromatography (ethyl acetate/hexane) to give the title compound (1.43 g).

Aufarbeitung

  1. customThe insoluble substance was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customThe obtained residue was purified by NH silica gel column chromatography (ethyl acetate/hexane)

Quellen und Nachweise

ORD-Eintrag
ord-dbf89bd7c938424387e80510ea411f7a
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09315458B2

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