(S)-2-((tert-butoxycarbonyl)amino)-3,3-bis(4-fluorophenyl)propanoic acid → tert-butyl (2S,5S)-2-[(2-{[N-(tert-butoxycarbonyl)-4-fluoro-beta-(4-fluorophenyl)-L-phenylalanyl]amino}-6-fluorophenoxy)methyl]-5-({[tert-butyl(dimethyl)silyl]oxy}methyl)morpholine-4-carboxylate

Reaktionsgleichung

O(Cl)Cl.[P+5].[NH2:5][C:6]1[CH:35]=[CH:34][CH:33]=[C:32]([F:36])[C:7]=1[O:8][CH2:9][C@H:10]1[O:15][CH2:14][C@@H:13]([CH2:16][O:17][Si:18]([C:21]([CH3:24])([CH3:23])[CH3:22])([CH3:20])[CH3:19])[N:12]([C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[CH2:11]1.[C:37]([O:41][C:42]([NH:44][C@H:45]([C:61](O)=[O:62])[CH:46]([C:54]1[CH:59]=[CH:58][C:57]([F:60])=[CH:56][CH:55]=1)[C:47]1[CH:52]=[CH:51][C:50]([F:53])=[CH:49][CH:48]=1)=[O:43])([CH3:40])([CH3:39])[CH3:38]>N1C=CC=CC=1>[C:37]([O:41][C:42]([NH:44][C@H:45]([C:61]([NH:5][C:6]1[CH:35]=[CH:34][CH:33]=[C:32]([F:36])[C:7]=1[O:8][CH2:9][C@H:10]1[O:15][CH2:14][C@@H:13]([CH2:16][O:17][Si:18]([C:21]([CH3:22])([CH3:23])[CH3:24])([CH3:20])[CH3:19])[N:12]([C:25]([O:27][C:28]([CH3:29])([CH3:30])[CH3:31])=[O:26])[CH2:11]1)=[O:62])[CH:46]([C:54]1[CH:59]=[CH:58][C:57]([F:60])=[CH:56][CH:55]=1)[C:47]1[CH:52]=[CH:51][C:50]([F:53])=[CH:49][CH:48]=1)=[O:43])([CH3:39])([CH3:40])[CH3:38]