3-Chloromethyl-2-propylsulfanyl-pyridine → {2-[3-Fluoro-4-(2-propylsulfanyl-pyridin-3-ylmethoxy)-phenyl]-cyclopropyl}-acetic acid

HRID 62992Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 62992
Cl[CH2:2][C:3]1[C:4]([S:9][CH2:10][CH2:11][CH3:12])=[N:5][CH:6]=[CH:7][CH:8]=1.C[O:14][C:15](=[O:28])[CH2:16][CH:17]1[CH2:19][CH:18]1[C:20]1[CH:25]=[CH:24][C:23]([OH:26])=[C:22]([F:27])[CH:21]=1>>[F:27][C:22]1[CH:21]=[C:20]([CH:18]2[CH2:19][CH:17]2[CH2:16][C:15]([OH:28])=[O:14])[CH:25]=[CH:24][C:23]=1[O:26][CH2:2][C:3]1[C:4]([S:9][CH2:10][CH2:11][CH3:12])=[N:5][CH:6]=[CH:7][CH:8]=1

Komponenten

3

Edukt 2

HCID 901182823-Chloromethyl-2-propylsulfanyl-pyridineHCID 90118358HCID 90118358, Verbindung

Produkt 1

HCID 90118128{2-[3-Fluoro-4-(2-propylsulfanyl-pyridin-3-ylmethoxy)-phenyl]-cyclopropyl}-acetic acidAusbeute 96 %

Versuchsvorschrift

3-Chloromethyl-2-propylsulfanyl-pyridine (0.024 g, 0.12 mmol) obtained in Step C of Preparation Example 14 and [2-(3-fluoro-4-hydroxy-phenyl)-cyclopropyl]-acetic acid methyl ester (0.027 g, 0.12 mmol) obtained in Step F of Preparation Example 53 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (0.043 g, 96%).

Aufarbeitung

  1. customto react sequentially in the same manner as in Steps A and B of Example 1

Quellen und Nachweise

ORD-Eintrag
ord-0dc526f2b92c4c3bae29b1636e9a28d7
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09447044B2

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