3-Chloromethyl-2-cyclopentylsulfanyl-pyridine → [6-(2-Cyclopentylsulfanyl-pyridin-3-ylmethoxy)-5,7-difluoro-benzofuran-3-yl]-acetic acid
Reaktionsgleichung
Cl[CH2:2][C:3]1[C:4]([S:9][CH:10]2[CH2:14][CH2:13][CH2:12][CH2:11]2)=[N:5][CH:6]=[CH:7][CH:8]=1.C[O:16][C:17](=[O:31])[CH2:18][C:19]1[C:23]2[CH:24]=[C:25]([F:30])[C:26]([OH:29])=[C:27]([F:28])[C:22]=2[O:21][CH:20]=1>>[CH:10]1([S:9][C:4]2[C:3]([CH2:2][O:29][C:26]3[C:25]([F:30])=[CH:24][C:23]4[C:19]([CH2:18][C:17]([OH:31])=[O:16])=[CH:20][O:21][C:22]=4[C:27]=3[F:28])=[CH:8][CH:7]=[CH:6][N:5]=2)[CH2:14][CH2:13][CH2:12][CH2:11]1Komponenten
3
Versuchsvorschrift
3-Chloromethyl-2-cyclopentylsulfanyl-pyridine (19 mg, 0.08 mmol) obtained in Step C of Preparation Example 8 and (5,7-difluoro-6-hydroxy-benzofuran-3-yl)-acetic acid methyl ester (20 mg, 0.08 mmol) obtained in Step C of Preparation Example 50 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (28 mg, 81%).