Phosphorus tribromide → 2-(Bromomethyl)-1-methyl-1H-benzimidazole hydrobromide

HRID 630034

Reaktionsgleichung

Reaktionsgleichung von HRID 630034
[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[N:4]=[C:3]1[CH2:11]O.P(Br)(Br)[Br:14]>ClCCl>[BrH:14].[Br:14][CH2:11][C:3]1[N:2]([CH3:1])[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[N:4]=1

Komponenten

4

Edukt 2

HCID 24614Phosphorus tribromideHCID 344177(1-methyl-1H-1,3-benzodiazol-2-yl)methanol

Produkt 1

HCID 242294512-(Bromomethyl)-1-methyl-1H-benzimidazole hydrobromide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of (1-methyl-1H-benzimidazol-2-yl)methanol (1.1 g, 6.8 mmol) in anhydrous dichloromethane (60 mL) was added dropwise phosphorus tribromide (1.3 mL, 14.0 mmol). The mixture was stirred at room temperature overnight. Dichloromethane was evaporated. The residue was dried in vacuo, affording 2-(bromomethyl)-1-methyl-1H-benzimidazole hydrobromide. The product was used without further purification.

Aufarbeitung

  1. customDichloromethane was evaporated
  2. customThe residue was dried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-0097ecac854d44488bcbc78e8c9c1f15
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09315521B2

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