Ethyl 3-(3-chloro-4-hydroxyphenyl)propanoate → 3-[3-Chloro-4-(6-cyclopentylsulfanyl-pyridin-2-ylmethoxy)-phenyl]-propionic acid
Reaktionsgleichung
Cl[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([S:9][CH:10]2[CH2:14][CH2:13][CH2:12][CH2:11]2)[N:4]=1.C([O:17][C:18](=[O:29])[CH2:19][CH2:20][C:21]1[CH:26]=[CH:25][C:24]([OH:27])=[C:23]([Cl:28])[CH:22]=1)C>>[Cl:28][C:23]1[CH:22]=[C:21]([CH2:20][CH2:19][C:18]([OH:29])=[O:17])[CH:26]=[CH:25][C:24]=1[O:27][CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([S:9][CH:10]2[CH2:14][CH2:13][CH2:12][CH2:11]2)[N:4]=1Komponenten
3
Versuchsvorschrift
2-Chloromethyl-6-cyclopentylsulfanyl-pyridine (46 mg, 0.20 mmol) obtained in Step C of Preparation Example 27 and 3-(3-chloro-4-hydroxy-phenyl)-propionic acid ethyl ester (51 mg, 0.22 mmol) obtained in Step C of Preparation Example 42 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (45 mg, 71%).
Aufarbeitung
- customto react sequentially in the same manner as in Steps A and B of Example 1