Diethylamine → HCID 59589465, Verbindung

HRID 630052Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 630052
Br[CH2:2][C:3]1[CH:4]=[CH:5][C:6]([Cl:12])=[C:7]([CH:11]=1)[C:8]([O-:10])=[O:9].[CH2:13]([NH:15][CH2:16][CH3:17])[CH3:14].[C:18](=O)([O-])[O-].[K+].[K+]>CC(C)=O>[Cl:12][C:6]1[CH:5]=[CH:4][C:3]([CH2:2][N:15]([CH2:16][CH3:17])[CH2:13][CH3:14])=[CH:11][C:7]=1[C:8]([O:10][CH3:18])=[O:9]

Komponenten

5

Edukt 3

HCID 8021DiethylamineHCID 11430Potassium CarbonateHCID 86647906HCID 86647906, Verbindung

Produkt 1

HCID 59589465HCID 59589465, VerbindungAusbeute 99,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

A mixture of 5-(bromomethyl)-2-chlorobenzoate (4.0 g, 15.6 mmol), diethylamine (5 mL, 48.1 mmol), and potassium carbonate (4.3 g, 31.2 mmol) in acetone (60 mL) was stirred at room temperature for 2 days. The solid material was removed by filtration. The filtrate was recovered, evaporated, and dried in vacuo, affording methyl 2-chloro-5-[(diethylamino)methyl]benzoate (3.97 g, 99% yield). The product was used without further purification.

Aufarbeitung

  1. customThe solid material was removed by filtration
  2. customThe filtrate was recovered
  3. customevaporated
  4. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-4dec5eee756a4bc4863ca84844f5ae36
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09315521B2

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