Phosphorus tribromide → Benzenemethanamine, 3-(bromomethyl)-4-chloro-N,N-diethyl-

HRID 630054Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 630054
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][N:9]([CH2:12][CH3:13])[CH2:10][CH3:11])=[CH:4][C:3]=1[CH2:14]O.P(Br)(Br)[Br:17]>ClCCl>[Br:17][CH2:14][C:3]1[CH:4]=[C:5]([CH2:8][N:9]([CH2:12][CH3:13])[CH2:10][CH3:11])[CH:6]=[CH:7][C:2]=1[Cl:1]

Komponenten

4

Edukt 2

HCID 24614Phosphorus tribromideHCID 59589352HCID 59589352, Verbindung

Produkt 1

HCID 66815196Benzenemethanamine, 3-(bromomethyl)-4-chloro-N,N-diethyl-

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of {2-chloro-5-[(diethylamino)methyl]phenyl}methanol (3.0 g, 13.2 mmol) in anhydrous dichloromethane (80 mL) was added dropwise phosphorus tribromide (2.5 mL, 26.4 mmol). The mixture was stirred at room temperature overnight. The solvent was evaporated. The residue was dried in vacuo, affording {[3-(bromomethyl)-4-chlorophenyl]methyl}diethylamine. The product was used without further purification.

Aufarbeitung

  1. customThe solvent was evaporated
  2. customThe residue was dried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-0c42fc26846741df9dbd7bc516541f0f
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09315521B2

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