Ethyl 3-(3-fluoro-4-hydroxyphenyl)propionate → 3-[4-(6-Cyclobutylsulfanyl-pyridin-2-ylmethoxy)-3-fluoro-phenyl]-propionic acid

HRID 63009Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 63009
Cl[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([S:9][CH:10]2[CH2:13][CH2:12][CH2:11]2)[N:4]=1.C([O:16][C:17](=[O:28])[CH2:18][CH2:19][C:20]1[CH:25]=[CH:24][C:23]([OH:26])=[C:22]([F:27])[CH:21]=1)C>>[CH:10]1([S:9][C:5]2[N:4]=[C:3]([CH2:2][O:26][C:23]3[CH:24]=[CH:25][C:20]([CH2:19][CH2:18][C:17]([OH:28])=[O:16])=[CH:21][C:22]=3[F:27])[CH:8]=[CH:7][CH:6]=2)[CH2:13][CH2:12][CH2:11]1

Komponenten

3

Edukt 2

HCID 3023769Ethyl 3-(3-fluoro-4-hydroxyphenyl)propionateHCID 901181462-Chloromethyl-6-cyclobutylsulfanyl-pyridine

Produkt 1

HCID 901183333-[4-(6-Cyclobutylsulfanyl-pyridin-2-ylmethoxy)-3-fluoro-phenyl]-propionic acidAusbeute 85 %

Versuchsvorschrift

2-Chloromethyl-6-cyclobutylsulfanyl-pyridine (0.030 g, 0.14 mmol) obtained in Step C of Preparation Example 37 and 3-(3-fluoro-4-hydroxy-phenyl)-propionic acid ethyl ester (0.030 g, 0.14 mmol) obtained in Step C of Preparation Example 6 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (0.043 g, 84%).

Aufarbeitung

  1. customto react sequentially in the same manner as in Steps A and B of Example 1

Quellen und Nachweise

ORD-Eintrag
ord-8c9c93a2d4e84824a0f0da44b838cf8e
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09447044B2

Notizen zur Reaktion

Wird geladen…