Thionyl Chloride → 5-(chloromethyl)-1-ethyl-4-methyl-1H-imidazole hydrochloride
Reaktionsgleichung
[CH2:1]([N:3]1[C:7]([CH2:8]O)=[C:6]([CH3:10])[N:5]=[CH:4]1)[CH3:2].S(Cl)([Cl:13])=O>ClCCl>[ClH:13].[Cl:13][CH2:8][C:7]1[N:3]([CH2:1][CH3:2])[CH:4]=[N:5][C:6]=1[CH3:10]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To (1-ethyl-4-methyl-1H-imidazol-5-yl)methanol (754 mg, 5.4 mmol) in anhydrous dichloromethane (35 mL) was added thionyl chloride (2 mL). The mixture was stirred at room temperature overnight. Dichloromethane was evaporated and then co-evaporated with toluene (2×15 mL). The residue was dried in vacuo, affording 5-(chloromethyl)-1-ethyl-4-methyl-1H-imidazole hydrochloride (1.0 g, 95% yield). The product was used without further purification.
Aufarbeitung
- customDichloromethane was evaporated
- customThe residue was dried in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-caefa0a20113467e942638622639e02f
- Quelldatensatz
- uspto-grants-2016_04
- Patentnummer
- US09315521B2
Notizen zur Reaktion
Wird geladen…