Phosphorus tribromide → 4-(Bromomethyl)-3,5-dichloropyridine hydrobromide
Reaktionsgleichung
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:10])[C:7]=1[CH2:8]O.[Br:11]P(Br)Br>ClCCl>[BrH:11].[Br:11][CH2:8][C:7]1[C:2]([Cl:1])=[CH:3][N:4]=[CH:5][C:6]=1[Cl:10]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To a solution of (3,5-dichloropyridin-4-yl)methanol (1.9 g, 10.7 mmol) in anhydrous dichloromethane (75 mL) was added tribromophosphane (1.1 mL, 11.5 mmol). The mixture was stirred at room temperature for 1.5 hours. Dichloromethane was evaporated, and the mixture was co-evaporated with toluene (2×20 mL). The residue was dried in vacuo, affording 4-(bromomethyl)-3,5-dichloropyridine hydrobromide (2.9 g, 98% yield), which was used without further purification.
Aufarbeitung
- customDichloromethane was evaporated
- customThe residue was dried in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-f2e1ff0fd508423db620085c0d8e7fcc
- Quelldatensatz
- uspto-grants-2016_04
- Patentnummer
- US09315521B2
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