4-tert-Butylbenzoic acid → 2-(4-Tert-butylphenyl)-1,3-benzoxazol-5-amine

HRID 63027

Reaktionsgleichung

Reaktionsgleichung von HRID 63027
[CH:1]1[C:6]([NH2:7])=[CH:5][C:4]([NH2:8])=[C:3]([OH:9])[CH:2]=1.Cl.Cl.[C:12]([C:16]1[CH:24]=[CH:23][C:19]([C:20](O)=O)=[CH:18][CH:17]=1)([CH3:15])([CH3:14])[CH3:13].[OH-].[Na+]>>[C:12]([C:16]1[CH:17]=[CH:18][C:19]([C:20]2[O:9][C:3]3[CH:2]=[CH:1][C:6]([NH2:7])=[CH:5][C:4]=3[N:8]=2)=[CH:23][CH:24]=1)([CH3:15])([CH3:14])[CH3:13]

Komponenten

4

Edukt 3

HCID 74034-tert-Butylbenzoic acidHCID 87152,4-Diaminophenol hydrochlorideHCID 14798Sodium Hydroxide

Produkt 1

HCID 7218812-(4-Tert-butylphenyl)-1,3-benzoxazol-5-amineAusbeute 94 %

Reaktionsbedingungen

Temperatur
180 °C

Versuchsvorschrift

8 mmol of 2,4-diaminophenol.2HCl and 8 mmol of 4-tert-butyl-benzoic acid were dissolved in 10 g of PPA, and then, the mixed solution was stirred at a temperature of 180° C. for 3 to 4 hours. After completion of the reaction, the reaction solution was cooled, neutralized with 10% NaOH, and filtered by using distilled water for recrystallization in a slow manner, thereby obtaining 2.0 g of 2-(4-tert-butylphenyl)benzo[d]oxazole-5-amine (Derivate #4) (yield: 94%).

Aufarbeitung

  1. customAfter completion of the reaction
  2. temperaturethe reaction solution was cooled
  3. filtrationfiltered
  4. distillationby using distilled water
  5. customfor recrystallization in a slow manner

Quellen und Nachweise

ORD-Eintrag
ord-59fabe50d9ef4db2b36ea564a9673d76
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09447054B2

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