Chloride → N-[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-methoxyphenyl]acrylamide

HRID 630412Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 630412
[Cl-].C(CC(CC)(NC(C)C)C)C.[Si:13]([O:20][CH2:21][C:22]1[C:27]([O:28][CH3:29])=[CH:26][C:25]([NH:30][C:31](=[O:34])[CH:32]=[CH2:33])=[C:24](Cl)[CH:23]=1)([C:16]([CH3:19])([CH3:18])[CH3:17])([CH3:15])[CH3:14]>>[Si:13]([O:20][CH2:21][C:22]1[CH:23]=[CH:24][C:25]([NH:30][C:31](=[O:34])[CH:32]=[CH2:33])=[CH:26][C:27]=1[O:28][CH3:29])([C:16]([CH3:19])([CH3:18])[CH3:17])([CH3:14])[CH3:15]

Komponenten

4

Edukt 3

HCID 312ChlorideHCID 67145019N-[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2-chloro-5-methoxyphenyl]-acrylamideHCID 129867302Diethyldiisopropylamine

Produkt 1

HCID 67469526N-[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-methoxyphenyl]acrylamide

Versuchsvorschrift

Obtained as a solid (63%) from [4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-methoxyphenyl]amine (intermediate 99; 5 g, 18.7 mmol), acryloil chloride (1.98 mL, 24.28 mmol) and diethyldiisopropylamine (4.9 mL, 28.06 mmol) following the experimental procedure as described in intermediate 40. The crude obtained was purified by column chromatography with silica gel, eluting with methylene chloride.

Aufarbeitung

  1. customThe crude obtained
  2. customwas purified by column chromatography with silica gel
  3. washeluting with methylene chloride

Quellen und Nachweise

ORD-Eintrag
ord-cdbbf9f8ce6f4afcaeb5d1ad7d278e1e
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09315463B2

Notizen zur Reaktion

Wird geladen…