2-Bromo-4-chloropyridine → (1-(5-(4-Chloropyridin-2-yl)pyrimidin-2-yl)-3-(methylsulfinyl)-1H-indol-6-yl)(morpholino)methanone

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	2-Bromo-4-chloropyridine	HCID 2762836	—
Edukt	(1-(5-Bromopyrimidin-2-yl)-3-(methylsulfinyl)-1H-indol-6-yl)(morpholino)methanone	HCID 118666026	—
Edukt	(1-(5-(4-(2-Hydroxypropan-2-yl)pyridin-2-yl)pyrimidin-2-yl)-3-(methylthio)-1H-indol-6-yl)(morpholino)methanone	HCID 118666145	—
Produkt	(1-(5-(4-Chloropyridin-2-yl)pyrimidin-2-yl)-3-(methylsulfinyl)-1H-indol-6-yl)(morpholino)methanone	HCID 118666088	—

Reaktionsschritte

Prepared from (1-(5-bromopyrimidin-2-yl)-3-(methylsulfinyl)-1H-indol-6-yl)(morpholino)-methanone (0.5 g, 1.11 mmol) and 2-bromo-4-chloropyridine (0.23 g, 1.22 mmol) analogously to the experimental procedure for 289a). White solid. Yield: 61 mg (11% of theory)

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US09315490B2
Quelldatensatz	uspto-grants-2016_04
ORD ID	ord-88aa0a80d8324aa69676cab35d892fd5
Quellennotiz	uspto-grants-2016_04