Hydrazine → 4-Hydrazinylpyridin-2(1H)-one

HRID 631653Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 631653
[NH2:1][NH2:2].O[C:4]1[C:5]([OH:10])=[N:6][CH:7]=[CH:8][CH:9]=1>COCCOC>[NH:1]([C:9]1[CH:8]=[CH:7][NH:6][C:5](=[O:10])[CH:4]=1)[NH2:2]

Komponenten

4

Edukt 2

HCID 9321HydrazineHCID 178516237HCID 178516237, Verbindung

Produkt 1

HCID 136108294-Hydrazinylpyridin-2(1H)-oneAusbeute 78 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 80711,2-DimethoxyethaneLösungsmittel

Versuchsvorschrift

To a solution of hydrazine (8 mL) in DME (40 mL) was added dihydroxypyridine (2.00 g, 18 mmol) and the reaction heated at reflux overnight. The solution was cooled to rt, and the solids removed by filtration. The filtrate was concentrated and the resulting solid crystallized from hot EtOH to afford 4-hydrazinylpyridin-2(1H)-one (1.75 g, 78% yield). LC-MS (ESI) m/z 126 (M+H)+.

Aufarbeitung

  1. temperaturethe reaction heated
  2. temperatureat reflux overnight
  3. customthe solids removed by filtration
  4. concentrationThe filtrate was concentrated
  5. customthe resulting solid crystallized from hot EtOH

Quellen und Nachweise

ORD-Eintrag
ord-7237a71d73034ee9ab2ff86d01f650e4
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09320739B2

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