Benzenesulfonyl chloride → HCID 68296414, Verbindung

HRID 631873Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 631873
[CH3:1][O:2][C:3]([C:5]1[C:14]2[CH2:13][CH2:12][CH2:11][CH2:10][C:9]=2[CH:8]=[CH:7][C:6]=1[NH2:15])=[O:4].[C:16]1([S:22](Cl)(=[O:24])=[O:23])[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>N1C=CC=CC=1>[CH3:1][O:2][C:3]([C:5]1[C:14]2[CH2:13][CH2:12][CH2:11][CH2:10][C:9]=2[CH:8]=[CH:7][C:6]=1[NH:15][S:22]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)(=[O:24])=[O:23])=[O:4]

Komponenten

4

Edukt 2

HCID 7369Benzenesulfonyl chlorideHCID 11521576Methyl 2-amino-5,6,7,8-tetrahydronaphthalene-1-carboxylate2×

Produkt 1

HCID 68296414HCID 68296414, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

To a solution of 2-amino-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid methyl ester (Intermediate 5, 1.5 g) in pyridine (20 mL) was added benzenesulfonyl chloride (0.95 mL). The mixture was stirred for 1 hour then concentrated under vacuum. The residue was dissolved in ethyl acetate and washed with 1N hydrochloric acid, dried with magnesium sulfate and filtered. The filtrate was evaporated under vacuum to give the title compound as an off-white crystalline solid (2.4 g).

Aufarbeitung

  1. concentrationthen concentrated under vacuum
  2. dissolutionThe residue was dissolved in ethyl acetate
  3. washwashed with 1N hydrochloric acid
  4. dry with materialdried with magnesium sulfate
  5. filtrationfiltered
  6. customThe filtrate was evaporated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-48cb155985cd49dc9c4d21d645420729
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09321740B2

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