HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Benzylamine → HCID 19805433, Verbindung
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Benzylamine | HCID 7504 | — |
| Edukt | 6-Methyl-2-nitrobenzoic acid | HCID 16097 | — |
| Edukt | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Lösungsmittel | Ethyl Acetate | HCID 8857 | — |
| Lösungsmittel | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Lösungsmittel | Diisopropylethylamine | HCID 81531 | — |
| Produkt | HCID 19805433 | HCID 19805433 | 75,5% |
Reaktionsschritte
2-Nitro-6-methylbenzoic acid (0.91 g) and benzylamine (0.53 g) were dissolved in NMP (5 mL) and DIPEA (3 mL). HATU (1.9 g) was added and the mixture was stirred for 1 hour. The reaction mixture was diluted with ethyl acetate and washed with 1N hydrochloric acid, saturated aqueous sodium bicarbonate and then brine. The organic solution was dried with magnesium sulfate, filtered and the solvent was removed under vacuum to give a light brown oil (1.01 g) that crystallized on standing.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09321740B2 |
| Quelldatensatz | uspto-grants-2016_04 |
| ORD ID | ord-1218be025e15465492c80ea8cb1c6832 |
| Quellennotiz | uspto-grants-2016_04 |