Acetic Acid → HCID 178527899, Verbindung

Beteiligte Stoffe

Reaktionsschritte

5-bromobenzo[d][1,3]dioxol-4-carbaldehyde (0.24 g, 1.05 mmol), IPA (4.8 ml), and 5-amino-1H-benzo[d]imidazole-2(3H)-thione (0.2 g, 1.21 mmol) were put in a 25 ml flask, and acetic acid (10 ml) was slowly added dropwise thereto while the mixture was stirred under nitrogen charging conditions, followed by stirring for 12 hours under reflux conditions. After that, the temperature of the mixture was lowered to room temperature, and the thus obtained solid was washed with methylene chloride and methanol, followed by filtering, thereby obtaining clean (E)-5-((6bromobenzo[d][1,3]dioxol-4-yl)methyleneamino)-1H-benzo[d]imidazole-2(3H)-thione at 83% yield.

Herkunft & Nachweise