Lawesson's reagent → tert-butyl N-(1-carbamothioyl-1-methylethyl)carbamate

HRID 631972Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 631972
[NH2:1][C:2](=O)[C:3]([NH:6][C:7](=[O:13])[O:8][C:9]([CH3:12])([CH3:11])[CH3:10])([CH3:5])[CH3:4].COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:24])=CC=1>C1(C)C=CC=CC=1>[NH2:1][C:2](=[S:24])[C:3]([NH:6][C:7](=[O:13])[O:8][C:9]([CH3:12])([CH3:11])[CH3:10])([CH3:5])[CH3:4]

Komponenten

4

Edukt 2

HCID 87949Lawesson's reagentHCID 11287144tert-Butyl (1-amino-2-methyl-1-oxopropan-2-yl)carbamate

Produkt 1

HCID 15186362tert-butyl N-(1-carbamothioyl-1-methylethyl)carbamateAusbeute 109,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

To a mixture of tert-butyl 1-amino-2-methyl-1-oxopropan-2-ylcarbamate (10 g, 49 mmol) in toluene (200 mL) was added Lawesson's reagent (CAN 19172-47-5, 10 g, 25 mmol). The suspension was heated to 90° C. and stirred for 6 h. After evaporation of solvents, the residue was purified by column chromatography (silica gel, 120 g) eluting with 30% ethyl acetate in petroleum ether to yield the title compound (6 g, 56%); MS: m/e 241.2 [M+Na]+.

Aufarbeitung

  1. customAfter evaporation of solvents
  2. customthe residue was purified by column chromatography (silica gel, 120 g)
  3. washeluting with 30% ethyl acetate in petroleum ether

Quellen und Nachweise

ORD-Eintrag
ord-73dd88e028bc4ba49c168440932ee5bc
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09321727B2

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